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Uninstall & Reinstall Issues

Fix Microsoft 365 Not Opening After Windows 10 Pro Install

Maira MehtabMaira Mehtab Sep 22, 2026 869 views

Question details

User is unable to open Microsoft Word, Excel, and PowerPoint after installing Windows 10 Pro, and standard reinstallation from the account page does not resolve the problem.

Product
Microsoft 365
Device & OS
Windows 10 Pro
Scenario
Attempting to access and run Office applications following a new Windows OS installation.
Observed behavior
Microsoft 365 applications fail to open, and performing a basic reinstall from the Microsoft account page yields no changes.
Before you start

Before proceeding, verify that your Microsoft 365 subscription is currently active by logging into your Microsoft account, and ensure you have administrator privileges on your Windows 10 Pro system.

Solution 1Recommended

Perform a Clean Uninstall and Reinstall of Microsoft 365

Since a basic reinstall did not work, you must completely remove corrupted Office files left behind during the Windows 10 Pro upgrade before attempting to install again.

Standard reinstallations often fail if corrupted registry keys or conflicting background services remain on the system. A complete removal followed by a restart ensures a clean slate.

1
Completely Uninstall Microsoft 365

Navigate to 'Settings' > 'Apps' > 'Apps & features' in Windows 10 Pro. Locate Microsoft 365 in the list, click on it, and select 'Uninstall'. Follow the prompts to remove the suite.

2
Restart Your Computer

Once the uninstallation is complete, restart your Windows 10 Pro device. This step is critical as it clears lingering temporary files and resets registry keys.

3
Reinstall from Microsoft Account

Go to www.office.com/myaccount and sign in with the Microsoft account associated with your active subscription. Click 'Install Office' and run the downloaded setup file to reinstall.

Account Verification: Ensure you are using the exact Microsoft account that holds the active Microsoft 365 license when downloading the installer.
Free Microsoft Office alternative

Try WPS Office for Seamless Productivity on Windows 10 Pro

If Microsoft 365 continues to face installation conflicts on your new Windows 10 Pro system, consider switching to WPS Office. It provides a highly compatible, free, and lightweight alternative to Microsoft Office, allowing you to open, edit, and save your Word, Excel, and PowerPoint files without interruption.

  1. 1. Download WPS Office: Visit the official WPS Office website and download the free installer for Windows.
  2. 2. Install the Application: Run the downloaded file and follow the quick setup wizard to install WPS Office on your Windows 10 Pro device.
  3. 3. Open Your Files: Launch WPS Office and directly open your existing Word, Excel, and PowerPoint documents with perfect formatting preservation.
Fully compatible with Microsoft Office formats including DOCX, XLSX, and PPTXFree and lightweight, ensuring smooth operation on Windows 10 Pro without heavy system resource usageFamiliar user interface for a seamless migration with zero learning curveAll-in-one software suite combining Writer, Spreadsheet, and Presentation tools
microsoft office alternative - wps office

Frequently Asked Questions

Why won't my Microsoft 365 apps open after installing Windows 10 Pro?

Upgrading or reinstalling an operating system can sometimes disrupt software registry paths, permissions, or background services required by Microsoft 365, causing the apps to fail upon launch.

Will uninstalling Microsoft 365 delete my saved documents?

No. Uninstalling Microsoft 365 only removes the application files from your computer. Your locally saved Word documents, Excel spreadsheets, and PowerPoint presentations remain safe on your hard drive.

How can I verify if my Microsoft 365 subscription is still active?

You can check your subscription status by signing in to www.office.com/myaccount with your Microsoft credentials and navigating to the 'Services & subscriptions' section.

What should I do if the Microsoft Support and Recovery Assistant cannot fix the issue?

If the official diagnostic tool fails, you may need to check for conflicting third-party antivirus software, verify Windows updates are fully installed, or consider using a highly compatible alternative like WPS Office to access your files immediately.