File Cannot Open

Fix Microsoft 365 Opening a Blank Window Instead of Excel 2010 Files

Bushra ParveenBushra Parveen Nov 3, 2026 868 views

Question details

Users are unable to view older Excel 2010 files after upgrading to Microsoft 365, as the application launches but only shows a gray or blank screen.

How to Fix Microsoft 365 Opening a Blank Window for Excel 2010 Files
Product
Microsoft 365 / Microsoft Excel
Device & OS
not provided
Scenario
Attempting to open legacy Excel 2010 workbooks (.xls or .xlsx) directly from the file explorer after installing Microsoft 365.
Observed behavior
The Excel application opens successfully but displays a completely blank window instead of loading the actual workbook data and cells.
Before you start

Verify whether this issue happens with every workbook or only specific files. It is highly recommended to create a copy of a non-confidential workbook and test it locally to ensure the original file is not corrupted.

Solution 1Recommended

Uncheck the Ignore DDE Setting in Excel

This is the most common fix when Excel opens a blank window instead of the actual file, as incorrect Dynamic Data Exchange (DDE) settings can block the application from receiving the file content.

When you double-click an Excel file in Windows, a DDE message is sent to Excel instructing it to open the file. If Excel is configured to ignore these messages, it will launch the application but fail to load the requested workbook.

1
Access Excel Options

Open a blank Microsoft Excel window. Click on 'File' in the top left corner, then select 'Options' at the bottom of the left-hand menu.

2
Navigate to Advanced Settings

In the Excel Options dialog box, click on the 'Advanced' tab on the left.

3
Disable the DDE Option

Scroll down to the 'General' section. Find the checkbox labeled 'Ignore other applications that use Dynamic Data Exchange (DDE)' and make sure it is unchecked. Click 'OK' to save your changes and try opening your Excel 2010 file again.

Uncheck the Ignore DDE Setting in Excel
Restart Excel: Make sure to completely close and restart Excel for the DDE setting changes to take full effect.
Free Microsoft Office alternative

Open Old Excel Files Easily with WPS Office

If Microsoft 365 continues to display blank windows when opening older Excel 2010 workbooks, switch to WPS Office. It is a free, lightweight alternative that bypasses Microsoft's legacy compatibility bugs and easily handles .xls and .xlsx formats.

  1. 1. Download WPS Office: Visit the official WPS Office website and download the free software for your device.
  2. 2. Install and Launch: Run the installation file and follow the on-screen prompts to set up WPS Office.
  3. 3. Open Your Legacy Files: Right-click your problematic Excel 2010 file, select 'Open with', and choose WPS Office to seamlessly view and edit your data.
Fully compatible with Microsoft Excel formats (.xls, .xlsx, .csv)Lightweight design ensures incredibly fast opening of older workbooksFree to use with a familiar tabbed interface, requiring zero learning curveAvoids complex DDE and macro errors commonly found in Microsoft 365
microsoft office alternative - wps office

Frequently Asked Questions

Why does Microsoft 365 open a blank screen instead of my Excel file?

This usually happens due to incorrect Dynamic Data Exchange (DDE) settings in Excel, corrupted file associations in Windows, or outdated third-party add-ins blocking the workbook's content from rendering.

How can I tell if my older Excel 2010 file is corrupted?

Try opening the file in another spreadsheet program, like WPS Office, or uploading it to a cloud service. If the file still fails to open or displays unreadable characters everywhere, the workbook itself is likely damaged.

Does Microsoft 365 still support older .xls files?

Yes, Microsoft 365 supports legacy .xls formats. However, strict Trust Center settings may sometimes block older files in Protected View for security reasons. You can adjust this by navigating to File > Options > Trust Center > Trust Center Settings > File Block Settings.